業績

  • 2015年4月以降の発表論文

    1.Takata N, Yoshida K, Komaki Y, Xu M, Sakai Y, Hikishima K, Mimura M, Okano H, Tanaka KF. Optogenetic activation of CA1 pyramidal neurons at the dorsal and ventral hippocampus evokes distinct brain-wide responses revealed by mouse fMRI. PLoS One. 10:e0121417, 2015
    大事なので再掲。

    2.Nautiyal KM, Tanaka KF, Barr MM, Tritschler L, Le Dantec Y, David DJ, Gardier AM, Blanco C, Hen R, Ahmari SE. Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity. Neuron. 86:813-826, 2015
    tTSによるknockdownを駆使した優れた論文。

    3.Yoshida K, Xu M, Natsubori A, Mimura M, Takata N, Tanaka KF. Identification of the extent of cortical spreading depression propagation by Npas4 mRNA expression. Neurosci Res. 98:1-8, 2015
    CSDの伝播について良く書かれている。

    4.Aida T, Chiyo K, Usami T, Ishikubo H, Imahashi R, Wada Y, Tanaka KF, Sakuma T, Yamamoto T, Tanaka K. Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice. Genome Biol. 16:87, 2015
    現在はKENGE-tetを相田さんのCRISPRで作っています。

    5.Masamoto K, Unekawa M, Watanabe T, Toriumi H, Takuwa H, Kawaguchi H, Kanno I, Matsui K, Tanaka KF, Tomita Y, Suzuki N. Unveiling astrocytic control of cerebral blood flow with optogenetics. Sci Rep5:11455, 2015
    慶應神経内科・電通大との共同研究。アストロサイト光刺激と血流といえば正本さん。

    6.Seo DO, Carillo MA, Chih-Hsiung Lim S, Tanaka KF, Drew MR. Adult Hippocampal Neurogenesis Modulates Fear Learning through Associative and Nonassociative Mechanisms. J Neurosci.35:11330-45, 2015
    Michael Drewとの共同研究。

    7.Ishii K, Kubo K, Endo T,Yoshida K, Benner S, Ito Y, Aizawa H, Aramaki M, Yamanaka A, Tanaka K, Takata N, Tanaka KF, Mimura M, Tohyama C, Kakeyama M, Nakajima K . Neuronal Heterotopias Affect the Activities of Distant Brain Areas and Lead to Behavioral Deficits. JNeurosci. 35:12432-45, 2015
    吉田君、お疲れ様。久保君、仲嶋先生との共同研究。

    8.Samuels BA, Anacker C, Hu A, Levinstein MR, Pickenhagen A, Tsetsenis T, Madroñal N, Donaldson ZR, Drew LJ, Dranovsky A, Gross CT, Tanaka KF, Hen R. 5-HT1A Receptors on Mature Dentate Gyrus Granule Cells are Critical for the Antidepressant Response Nat Neurosci18: 1606-1616, 2015
    セロトニン1A受容体floxマウスを作成。論文受理まで8年かかった。

    9.Nagai T, Takata N, Shinohara Y, Hirase H. Adaptive changes of extracellular amino acid concentrations in mouse dorsal striatum by 4-AP-induced cortical seizures Neuroscience295:229-236, 2015.

    10.Tsutsui-Kimura I, Ohmura Y, Izumi T, Matsushima T, Amita H, Yamaguchi T, Yoshida T, Yoshioka M. Neuronal codes for the inhibitory control of impulsive actions in the rat infralimbic cortex. Behav Brain Res. 296:361-72, 2016.

    11.Trischler J, Shiomi T, Turner DL, Sklepkiewicz PL, Goldklang MP, Tanaka KF, Xu M, Farber DL, D'Armiento JM. Immune Modulation of the T Cell Response in Asthma through Wnt10b. Am J Respir Cell Mol Biol. 54(4):584-93, 2016
    Wnt10bのSTOP-tetOマウス。潮見君との共同研究。

    12.Satała G, Duszyńska B, Stachowicz K, Rafalo A, Pochwat B, Luckhart C, Albert PR, Daigle M, Tanaka KF, Hen R, Lenda T, Nowak G, Bojarski AJ, Szewczyk B (9/14). Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies. Mol Neurobiol. 53(10):6869-6881, 2016
    Rene Henとの共同研究。

    13.Zhou Z, Tanaka KF, Matsunaga S, Iseki M, Watanabe M, Matsuki N, Ikegaya Y, Koyama R. Photoactivated adenylyl cyclase (PAC) reveals novel mechanisms underlying cAMP-dependent axonal morphogenesis. Sci Rep.;5:19679. 2016
    PACの最初の論文。亡き渡辺先生に合掌。小山君、御苦労様。

    14.Nakayama R, Sasaki T, Tanaka KF, Ikegaya Y. Subcellular calcium dynamics during juvenile development in mouse hippocampal astrocytes. Eur J Neurosci.43(7):923-932, 2016
    Astro-YCを使用。

    15.Chiba T, Otani Y, Yamaguchi Y, Ishibashi T, Hayashi A, Tanaka KF, Yamazaki M, Sakimura K, Baba H. Microglial phospholipase D4 deficiency influences myelination during brain development. Proc Jpn Acad Ser B Phys Biol Sci.92(7):237-54, 2016
    PLD4のSTOP-tetOノックインマウス。とっしーの上司である馬場先生との共同研究。

    16.Shimizu T, Osanai Y, Tanaka KF, Abe M, Natsume R, Sakimura K, Ikenaka K. YAP functions as a mechanotransducer in oligodendrocyte morphogenesis and maturation. Glia. 2016 in press, doi: 10.1002/glia.23096.
    YAPのSTOP-tetOノックインマウス。池中研の清水君との共同研究。

    17.Yoshida K, Mimura Y, Ishihara R, Nishida H,Komaki Y, Minakuchi T, Tsurugizawa T, Mimura M, Okano H, Tanaka KF, Takata N. Physiological effects of a habituation procedure for functional MRI in awake mice using a cryogenic radiofrequency probe. J Neurosci Methods. 274:38-48, 2016
    覚醒下fMRIのための馴化論文。

    18.Sugio H, Tohyama K, Oku S, Fujiyoshi K, Yoshimura T, Hikishima K, Yano R, Fukuda T, Nakamura M, Okano H, Watanabe M, Fukata M, Ikenaka K, Tanaka KF. Astrocyte-mediated infantile-onset leukoencephalopathy mouse model. Glia65 (1): 150-168, 2017
    Mlc1のSTOP-tetOノックインマウスによってノックアウトを、Mlc1のtetOノックインマウスとMlc1-tTAマウスの組み合わせで過剰発現を行った。労作。

    19.Tsutsui-Kimura I, Takiue H, Yoshida K, Xu M, Yano R, Ohta H, Nishida H, Bouchekioua Y, Okano H, Uchigashima M, Watanabe M, Takata N, Drew MR, Sano H, Mimura M, Tanaka KF. Dysfunction of ventrolateral striatal dopamine receptor type 2-expressing medium spiny neurons impairs instrumental motivation. Nat Communications 8: 14304, 2017
    代表作の一つ。DTAによるablationと南部・佐野式電気生理によるdysfunctionの証明、optogenetic inhibition、optogenetics ablation、オペラント学習のてんこ盛り。

    20.Natsubori A, Tsutsui-Kimura I, Nishida H, Bouchekioua Y, Sekiya H, Uchigashima M, Watanabe M, de Kerchove d'Exaerde A, Mimura M, Takata N, Tanaka KF. Ventrolateral Striatal Medium Spiny Neurons Positively Regulate Food-Incentive, Goal-Directed Behavior Independently of D1 and D2 Selectivity. J Neurosci. 37(10):2723-2733.
    Yellow cameleonを検出するfiberphotometry法を独自に開発(関谷さん、ありがとう)。次に繋がる論文。

    21.Shimizu T, Wisessmith W, Li J, Abe M, Sakimura K, Chetsawang B, Sahara Y, Tohyama K, Tanaka KF, Ikenaka K. The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model.
    Glia 65(6): 917-930, 2017
    Cathepsin C, Cystatin FのSTOP-tetO knockinを用いた論文。池中研の仕事。
  • 22. Tsutsui-Kimura I, Bouchekioua Y, Mimura M, Tanaka KF.
    A new paradigm for evaluating avoidance/escape motivation.
    Int J Neuropsychopharmacol.2017 May 6. doi: 10.1093/ijnp/pyx031.
    嫌なものから逃れる意欲を定量する行動解析を木村さんが作りました。

    23. Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K,Tanaka KF, Koizumi S.
    Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation.
    Cell Rep.19(6):1151-1164, 2017
    P2Y1 tetO knockinを利用した論文。小泉修一ラボとの共同研究です。

    24. Zike ID, Chohan MO, Kopelman JM, Krasnow EN, Flicker D, Nautiyal KM, Bubser M, Kellendonk C, Jones CK, Stanwood G,Tanaka KF, Moore H, Ahmari SE, Veenstra-VanderWeele J.
    OCD candidate gene SLC1A1/EAAT3 impacts basal ganglia-mediated activity and stereotypic behavior.
    Proc Natl Acad Sci U S A. 114(22):5719-5724 2017
    神経細胞に発現するグルタミン受容体EAAT3をSTOP-tetO cassette knockinで落とした仕事。当初Susanne Ahmariとの共同研究です。

    25. Kubo KI, Deguchi K, Nagai T, Ito Y, Yoshida K, Endo T, Benner S, Shan W, Kitazawa A, Aramaki M, Ishii K, Shin M, Matsunaga Y, Hayashi K, Kakeyama M, Tohyama C, Tanaka KF, Tanaka K, Takashima S, Nakayama M, Itoh M, Hirata Y, Antalffy B, Armstrong DD, Yamada K, Inoue K, Nakajima K.
    Association of impaired neuronal migration with cognitive deficits in extremely preterm infants.
    JCI Insight.2017 May 18;2(10). pii: 88609. doi: 10.1172/jci.insight.88609.
    解剖久保君の力作。吉田君が手伝いました。

    26. Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue KI, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Waschek JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K, Baba A, Hashimoto H.
    High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates.
    Neuron.94(6):1085-1100.e6. 2017
    大阪大学薬学部の橋本均先生との共同研究。彼らの粘り強さに感服です。勢力さん、笠井さん、丹生さんはマウス精神疾患MRI研究会のメンバーでもあります。一つ困ったのは、ここでもFASTというacronymを使っていることです。被った。

    27. Imada T, Nakamura S, Hisamura R, Izuta Y, Jin K, Ito M, Kitamura N, Tanaka KF, Mimura M, Shibuya I, Tsubota K.
    Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor.
    Sci Rep.7(1):6965, 2017
    チームごきげんとの共同研究。涙腺に発現するセロトニン受容体の全アイソフォームを検討しました。今田さん、頑張りました。良い仕事です。
  • 28. Abe Y, Tsurugizawa T, Le Bihan D.
    Water diffusion closely reveals neural activity status in rat brain loci affected by anesthesia.
    PLoS Biol.2017 Apr 13;15(4):e2001494. doi: 10.1371/journal.pbio.2001494.
    ポスドク阿部さんのフランス留学中のお仕事①。Diffusion functional MRIのメカニズムを麻酔と薬理を用いて証明した。

    29. Abe Y, Van Nguyen K, Tsurugizawa T, Ciobanu L, Le Bihan D.
    Modulation of water diffusion by activation-induced neural cell swelling in Aplysia Californica.
    Sci Rep.2017 Jul 21;7(1):6178. doi: 10.1038/s41598-017-05586-5.
    ポスドク阿部さんのフランス留学中のお仕事②。Diffusion functional MRIのメカニズムをアメフラシとMRI micro-imagingを用いて証明した。
  • 30. Madsen PM, Pinto M, Patel S, McCarthy S, Gao H, Taherian M, Karmally S, Pereira CV, Dvoriantchikova G, Ivanov D,Tanaka KF, Moraes CT, Brambilla R.
    Mitochondrial DNA Double-Strand Breaks in Oligodendrocytes Cause Demyelination, Axonal Injury, and CNS Inflammation.
    J Neurosci.2017 Oct 18;37(42):10185-10199.
  • 31.Bouchekioua Y, Tsutsui-Kimura I, Sano H, Koizumi M, Tanaka KF, Yoshida K,Kosaki Y, Watanabe S, Mimura M.
    Striatonigral direct pathway activation is sufficient to induce repetitive behaviors.
    Neurosci Res.2017 Sep 20. pii: S0168-0102(17)30454-6.
  • 32. Tsutsui-Kimura I, Natsubori A, Mori M, Kobayashi K, Drew MR, de Kerchove d'Exaerde A, Mimura M, Tanaka KF.
    Distinct Roles of Ventromedial versus Ventrolateral Striatal Medium Spiny Neurons in Reward-Oriented Behavior.
    Curr Biol.2017 Oct 9;27(19):3042-3048.

  • 33. Watabe T, Xu M, Watanabe M, Nabekura J, Higuchi T, Hori K, Sato MP, Nin F, Hibino H, Ogawa K, Masuda M, Tanaka KF.
    Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice.
    Sci Rep. 2017 Oct 19;7(1):13605. doi: 10.1038/s41598-017-13997-7.

  • 34. Sato MP, Higuchi T, Nin F, Ogata G, Sawamura S, Yoshida T, Ota T, Hori K, Komune S, Uetsuka S, Choi S, Masuda M, Watabe T, Kanzaki S, Ogawa K, Inohara H, Sakamoto S, Takebayashi H, Doi K, Tanaka KF, Hibino H.
    Hearing Loss Controlled by Optogenetic Stimulation of Nonexcitable Nonglial Cells in the Cochlea of the Inner Ear.
    Front Mol Neurosci. 2017 Sep 21;10:300. doi: 10.3389/fnmol.2017.00300. eCollection 2017.
    特に蝸牛血管条の光刺激研究は日比野研の力を存分に発揮した素晴らしい内容です。
  • 35. Yano R, Hata J, Abe Y, Seki F, Yoshida K, Komaki Y, Okano H, Tanaka KF.
    Quantitative temporal changes in DTI values coupled with histological properties in cuprizone-induced demyelination and remyelination.
    Neurochem Int.2017 Oct 10. pii: S0197-0186(17)30350-9.
  • 36. Vahid-Ansari F, Daigle M, Manzini MC, Tanaka KF, Hen R, Geddes SD, Béïque JC, James J, Merali Z, Albert PR.
    Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior.
    J Neurosci.2017 Dec 6;37(49):11967-11978.
  • 37. Good JM, Mahoney M, Miyazaki T, Tanaka KF, Sakimura K, Watanabe M, Kitamura K, Kano M.
    Maturation of Cerebellar Purkinje Cell Population Activity during Postnatal Refinement of Climbing Fiber Network.
    Cell Rep. 2017 Nov 21;21(8):2066-2073.
  • 38. Shigetomi E, Hirayama YJ, Ikenaka K, Tanaka KF, Koizumi S.
    Role of Purinergic Receptor P2Y1 in Spatiotemporal Ca2+ Dynamics in Astrocytes.
    J Neurosci.2018 Feb 7;38(6):1383-1395.
  • 39. Saito K, Shigetomi E, Yasuda R, Sato R, Nakano M, Tashiro K, Tanaka KF, Ikenaka K, Mikoshiba K, Mizuta I, Yoshida T, Nakagawa M, Mizuno T, Koizumi S.
    Aberrant astrocyte Ca2+ signals "AxCa signals" exacerbate pathological alterations in an Alexander disease model.
    Glia. 2018 Jan 31. doi: 10.1002/glia.23300.
  • 40. Chen S, Weitemier AZ, Zeng X, He L, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Teh DBL, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X, McHugh TJ.
    Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics
    Science 2018 Feb 9; 359(6376):679-684.


  • 総説など
    1. Natsubori A, Takata N, Tanaka KF. Observation and manipulation of glial cell function by virtue of sufficient probe expression. Front Cell Neurosci. 9:176, 2015

    2. 田中謙二、精神医学にオプトジェネティクスが期待されること、精神医学とオプトジェネティクス. 光アライアンス 26(6), pp33-36, 2015

    3. 木村 生、田中 謙二、オプトジェネティクス研究の変遷とこれから 実験医学 33(19), 3054-3058, 2015

    4. 田中謙二、観察と操作の両輪を走らせる研究にシフトせよ. 実験医学 33(19), 3044-3048,2015

    5. 田中謙二、遺伝子改変を駆使したグリア研究の推進 神経化学 54(3), 41-50, 2015

    6. 田中謙二、オプトジェネティクスの精神医学への応用 日本レーザー医学会誌36(4), 478-481, 2016

    7. 田中謙二、オプトジェネティクスに期待される非興奮性細胞の新たな操作技術 生化学 88(2), 198-201, 2016

    8. 阿部欣史、田中謙二、DREADD-CNO system 分子精神医学 18(1), 46-47



    寄付講座第Ⅰ期の業績(FY2012-2014)

    慶應に移籍するまでの発表論文のうち重要なもの
  •