寄付講座第Ⅰ期の業績（FY2012-2014）

  • 《英文著書》

    Inamura N, Sugio S, Macklin WB, Tomita K, Tanaka KF, Ikenaka K. Gene induction in mature oligodendrocytes with a PLP-tTA mouse line.
    Genesis. 2012 May;50(5):424-4

    Tanaka KF, Matsui K, Sasaki T, Sano H, Sugio S, Fan K, Hen R, Nakai J, Yanagawa Y, Hasuwa H, Okabe M, Deisseroth K, Ikenaka K, Yamanaka A. Expanding the Repertoire of Optogenetically Targeted Cells with an Enhanced Gene Expression System.
    Cell Rep. 2012 Aug 30;(2)2:397-406

  • Tanaka KF, Samuels BA, Hen R. Serotonin receptor expression along the dorsal-ventral axis of mouse hippocampus. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 5;367(1601):2395-2401

  • Okada Y, Sasaki T, Oku Y, Takahashi N, Seki M, Ujita S, Tanaka KF, Matsuki N, Ikegaya Y. Preinspiratory calcium rise in putative pre-Botzinger complex astrocytes. Physiol. 2012 Oct 1;590(Pt 19):4933-4944

  • Baudouin SJ, Gaudias J, Gerharz S, Hatstatt L, Zhou K, Punnakkal P, Tanaka KF, Spooren W, Hen R, De Zeeuw CI, Vogt K, Scheiffele P. Shared Synaptic Pathophysiology in Syndromic and Nonsyndromic Rodent Models of Autism. Science. 2012 Oct 5;338(6103):128-132

  • Sasaki T, Beppu K, Tanaka KF, Fukazawa Y, Shigemoto R, Matsui K. Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20720-20725

  • Bepari AK, Sano H, Tamamaki N, Nambu A, Tanaka KF, Takebayashi H. Identification of optogenetically activated striatal medium spiny neurons by npas4 expression. PLoS One. 2012;7(12):e52783

  • Koizumi A, Tanaka KF, Yamanaka A. The manipulation of neural and cellular activities by ectopic expression of melanopsin.
    Neurosci Res. 2013 Jan;75(1):3-5

  • Tsunematsu T, Tanaka KF, Yamanaka A, Koizumi A. Ectopic expression of melanopsin in orexin/hypocretin neurons enables control of wakefulness of mice in vivo by blue light. Neurosci Res. 2013 Jan;75(1):23-28

  • Lee HU, Yamazaki Y, Tanaka KF, Furuya K, Sokabe M, Hida H, Takao K, Miyakawa T, Fujii S, Ikenaka K. Increased astrocytic ATP release results in enhanced excitability of the hippocampus. Glia. 2013 Feb;61(2):210-214

  • Takata N, Nagai T, Ozawa K, Oe Y, Mikoshiba K, Hirase H. Cerebral blood flow modulation by Basal forebrain or whisker stimulation can occur independently of large cytosolic Ca2+ signaling in astrocytes. PLoS One. 2013 Jun 13;8(6):e66525

  • Tabuchi S, Tsunematsu T, Kilduff TS, Sugio S, Xu M, Tanaka KF, Takahashi S, Tominaga M, Yamanaka A. Influence of inhibitory serotonergic inputs to orexin/hypocretin neurons on the diurnal rhythm of sleep and wakefulness. Sleep. 2013 Sep 1;36(9):1391-1404
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  • Tsunematsu T, Tabuchi S, Tanaka KF, Boyden ES, Tominaga M, Yamanaka A. Long-lasting silencing of orexin/hypocretin neurons using archaerhodopsin induces slow-wave sleep in mice. Behav Brain Res. 2013 Oct 15;255:64-74

  • Shimizu T, Tanaka KF, Takebayashi H, Higashi M, Wisesmith W, Ono K, Hitoshi S, Ikenaka K. Olig2-lineage cells preferentially differentiate into oligodendrocytes but their processes degenerate at the chronic demyelinating stage of proteolipid protein-overexpressing mouse. J Neurosci Res. 2013 Feb;91(2):178-186

  • Beppu K, Sasaki T, Tanaka KF, Yamanaka A, Fukazawa Y, Shigemoto R, Matsui K. Optogenetic countering of glial acidosis suppresses glial glutamate release and ischemic brain damage. Neuron. 2014 Jan 22;81(2):314-320

  • Tsunematsu T, Ueno T, Tabuchi S, Inutsuka A, Tanaka KF, Hasuwa H, Kilduff TS, Terao A, Yamanaka A. Optogenetic manipulation of activity and temporally controlled cell-specific ablation reveal a role for MCH neurons in sleep/wake regulation. J Neurosci. 2014 May 14;34(20):6896-6909

  • Denny CA, Kheirbek MA, Alba EL, Tanaka KF, Brachman RA, Laughman KB, Tomm NK, Turi GF, Losonczy A, Hen R. Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. Neuron. 2014 Jul 2;83(1):189-201

  • Kanemaru K, Sekiya H, Xu M, Satoh K, Kitajima N, Yoshida K, Okubo Y, Sasaki T, Moritoh S, Hasuwa H, Mimura M, Horikawa K, Matsui K, Nagai T, Iino M, Tanaka KF. In vivo visualization of subtle, transient, and local activity of astrocytes using an ultrasensitive Ca(2+) indicator.
    Cell Rep. 2014 Jul 10;8(1):311-318

  • Yamazaki Y, Fujiwara H, Kaneko K, Hozumi Y, Xu M, Ikenaka K, Fujii S, Tanaka KF. Short- and long-term functional plasticity of white matter induced by oligodendrocyte depolarization in the hippocampus. Glia.2014 Aug;62(8):1299-1312

  • Fujii S, Tanaka KF, Ikenaka K, Yamazaki Y. Increased adenosine levels in mice expressing mutant glial fibrillary acidic protein in astrocytes result in failure of induction of LTP reversal (depotentiation) in hippocampal CA1 neurons. Brain Res. 2014 Aug 26;1578:1-13

  • Yamanaka Y, Hashimoto S, Masubuchi S, Natsubori A, Nishide SY, Honma S, & Honma K. Differential regulation of circadian melatonin rhythm and sleep-wake cycle by bright lights and non-photic time cues in humans. Am J Physiol Regul Integr Comp Physiol. 2014 Sep 1;307(5):R546-547

  • Miyazaki KW, Miyazaki K, Tanaka KF, Yamanaka A, Takahashi A, Tabuchi S, Doya K. Optogenetic activation of dorsal raphe serotonin neurons enhances patience for future rewards. Curr Biol. 2014 Sep 8;24(17):2033-2040

  • Ohmura Y, Tanaka KF, Tsunematsu T, Yamanaka A, Yoshioka M. Optogenetic activation of serotonergic neurons enhances anxiety-like behaviour in mice. Int J Neuropsychopharmacol. 2014 Nov;17(11):1777-1783

  • Tsutsui-Kimura I, Ohmura Y, Izumi T, Yoshida T, Yoshioka M. Milnacipran Remediates Impulsive Deficits in Rats with Lesions of the Ventromedial Prefrontal Cortex. Int J Neuropsychopharmacol. 2014 Dec 8;18(5):pyu083

  • Bouchekioua Y, Mimura M, Watanabe S. Air flow cued spatial learning in mice. Anim Cogn. 2015 Jan;18(1):399-404

    Aida T, Yoshida J, Nomura M, Tanimura A, Iino Y, Soma M, Bai N, Ito Y, Cui W, Aizawa H, Yanagisawa M, Nagai T, Takata N, Tanaka KF, Takayanagi R, Kano M, Götz M, Hirase H, Tanaka K. Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice. Neuropsychopharmacology. 2015 Feb 9;Epub ahead of print

    Takata N, Yoshida K, Komaki Y, Xu M, Sakai Y, Hikishima K, Mimura M, Okano H, Tanaka KF. Optogenetic activation of CA1 pyramidal neurons at the dorsal and ventral hippocampus evokes distinct brain-wide responses revealed by mouse fMRI. PLoS One. 2015 Mar 20;10(3):e0121417
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  • 《英語総説》

  • Takata N, Shinohara Y, Ohkura M, Mishima T, Nakai J, Hirase H. Imaging of Astrocytic Activity in Living Rodents. Neuromethods. 2014;85:191-207

    Hirase H, Iwai Y, Takata N, Shinohara Y, Mishima T. Volume transmission signaling via astrocytes. Phil. Trans. R. Soc. B. 2014;369:20130604


  • 《日本語総説》

  • 田中謙二　
    オプトジェネティクスと精神疾患研究への応用
    分子精神医学　Vol.12, No.3, 30-33, 2012

  • 田中謙二　
    線条体操作から強迫性障害を理解できるか　
    BRAIN and NERVE　Vol.64, No. 8, 903-909, 2012

  • 田中謙二、高田則雄、三村將　
    in vivoでグリアを見る・操作するための機能遺伝子発現方法
    実験医学　Vol.31, No.11, 1736-1741, 2013

  • 田中謙二、高田則雄、三村將　
    精神疾患の解明に貢献する脳科学技術の進歩　オプトジェネティクスと精神医学　
    精神神経学雑誌　Vol.115, No.12, 1211-1215, 2013

    田中謙二　
    マウスを用いたオプトジェネティクス研究　
    オプトジェネティクス―光工学と遺 伝子学による行動抑制技術の最前線―　160-167, 2013

  • 高田則雄　
    光遺伝学とマウスfMRIとを融合させた脳領域間作用の解析　
    細胞工学　Vol.33, No.3, 281-285, 2014

  • 田中謙二　
    オプトジェネティクス　
    精神医学　Vol.56, No.4, 281-284, 2014

  • 田中謙二　
    オプトジェネティクスを始めましょう　
    日本薬理学雑誌　Vol.143, No.4, 193-197, 2014

  • 夏堀晃世、田中謙二　
    Optogeneticsが拓く精神疾患の未来　
    Medical Science Digest　Vol.40, No.5, 13-15, 2014

  • 田中優衣、日野宇太郎、田中謙二　
    遺伝子改変マウスを"小さく"維持するコツ　
    実験医学　Vol.32, No.11, 2973-2979, 2014

  • 田中謙二、三村將、高田則雄　
    オプトジェネティクスと小動物functional MRIの融合による脳内環境変化の解析　
    遺伝子医学 MOOK26号 脳内環境－維持機構と破綻がもたらす疾患研究　125-129, 2014

  • 田中謙二　
    MicrodialysisとOptogenetics　
    分子のささやきを聴く マイクロダイアリシス研究のあゆみと展開　129-136, 2014

  • 小泉美和子　
    食欲の研究とマイクロダイアリシス-脳と全身から人間の食生活を考える-　
    分子のささやきを聴く マイクロダイアリシス研究のあゆみと展開　75-88, 2014